CRIPTOCOCOZA

Etiologie: Cryptococcus neoformans

rezervor principal: dejectiile porumbeilor

aspect: capsula gelatinoasa (polizaharidica)

PAS+, mucicarmin+

Factori favorizanti: corticoterapia, imunodepresia

Manifestari clinice

meningoencefalita - adulti imunocompetenti (rar)

Infectii oportuniste: AIDS, leucemie, limfom, LES, sarcoidoza, transplant

Patogeneza

cale respiratorie

imunocompetenti leziune pulmonara minima, asimptomatica fibroza

deficiente ale imunitatii celulare - inmultire locala diseminare

Anatomie patologica

SNC!!  

leptomeninge

creier: s. cenusie, nc bazali

plaman

afectare difuza sau focare de consolidare

localizari rare

piele, ficat, splina, suprarenale, oase

microscopie

imunodeprimati infiltrat inflamator cronic

imunocompetenti granuloame: Mf, Li, cel. gigante de corp strain

PMN

arterita

plus ag. etiologic!